Euclidean Distance Degree via Mixed Volume The Euclidean distance degree (EDD) of a variety X in R^n measures the algebraic complexity of computing the point of X closest to a general point u in R^n. It is the number of critical points of the complexified distance function from u to X. Known formulas involve polar classes of the conormal variety to X or Chern classes of X. In this talk, I will discuss formulas of a different character, when X is a hypersurface whose defining equation is general given its Newton polytope. In this case, the EDD is shown to be the mixed volume of the critical point equations. This uses Bernstein's Other Theorem, which is of independent interest. We give an interesting closed formula for the EDD when the Newton polytope is a rectangular parallelepiped. This is joint work with Paul Breiding and James Woodcock.